Vilon is a high-purity, research-grade synthetic dipeptide developed for laboratory studies of immune regulation, thymic cell function, and gene-level control in target cells.
Molecular Composition and Mechanistic Profile
Vilon (Lys-Glu, or KE): A two-amino-acid peptide with the sequence lysine-glutamic acid. Molecular weight is approximately 275 Da (formula C11H21N3O5). It was identified as a minimal active fragment from thymic extracts within the Khavinson bioregulator series and is one of the shortest peptides studied in this framework.
Structural characteristics: The small size supports cell and nuclear penetration along with proposed interactions with DNA and chromatin. Research models suggest it can influence chromatin structure (including decondensation of heterochromatin regions), gene expression related to immune cell differentiation, and pathways involving cytokines, proliferation markers, and DNA repair proteins such as sirtuins and PARPs.
Experimental data from the originating research program indicate associations with support for T-cell related markers, modulation of inflammatory cytokine profiles in certain models, chromatin remodeling in aged lymphocytes, and lifespan or tumor incidence effects in rodent studies when administered chronically.
Integrated Research Applications
Vilon is formulated to support focused investigation of short-peptide effects on immune and related pathways. Representative research domains include:
In vitro models examining lymphocyte or thymic cell differentiation markers, gene expression patterns, chromatin structure, and cellular responses under controlled or aging-related conditions.
Preclinical studies of immune modulation, recovery after stress or challenge, spontaneous tumor incidence, and lifespan parameters in rodent models.
Exploratory work on DNA repair signaling, cytokine balance, and interactions with other short bioregulators.
Using Vilon as a single, well-characterized entity allows researchers to evaluate tissue-oriented signaling without the variability of complex tissue extracts.
Analytical Validation and Quality Assurance
Commercial research preparations of Vilon are typically specified at high purity (often ≥98–99%) and characterized by HPLC and mass spectrometry. These methods confirm identity, sequence integrity, and batch consistency for laboratory use.
Storage and Stability Guidelines
Proper storage preserves structural integrity and experimental reproducibility. Typical guidance for lyophilized Vilon includes:
Room temperature (unopened, lyophilized): Suitable for limited periods when sealed, dry, and protected from light.
Refrigerated storage (2–8 °C): Appropriate for medium-term maintenance of unopened or reconstituted material used over days to weeks.
Frozen storage (≤ −20 °C, preferably lower for long-term): Recommended for extended timelines, with vials kept well sealed to limit moisture and degradation.
Reconstituted solutions are generally stored cold, protected from light, and used within a defined experimental window according to local lab practices to maintain activity and limit contamination risk.
