How is DY-131 packaged?
DY-131 is supplied in the product format and quantity shown for the selected variant. Please inspect the sealed package when it arrives and contact support promptly if the package or labeling appears damaged.
DY-131
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DY-131 research material, a small-molecule ERR-beta and ERR-gamma agonist. Assayed for purity and identity, with the certificate of analysis published.
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Product details
DY131 is a synthetic selective agonist of estrogen related receptors investigated for its interactions with ERRβ and ERRγ signaling pathways in preclinical models of cellular energy regulation.
Molecular Composition and Mechanistic Profile
Compound identity: DY131 is a small molecule agonist with the molecular formula C18H21N3O2.
Origin: Synthetic compound developed as a pharmacological tool for studying orphan nuclear receptor activity.
Mechanistically, DY131 has been associated with:
Selective activation of estrogen related receptors β and γ in experimental binding and transcriptional assays.
Modulation of downstream pathways involved in energy metabolism and mitochondrial function in laboratory systems.
Influence on gene expression programs regulated by ERRβ and ERRγ in cellular preparations.
These properties position DY131 as a tool for studying selective estrogen related receptor signaling and metabolic regulation.
Integrated Research Applications
DY131 is examined in systems focused on nuclear receptor and energy homeostasis research. Representative domains include:
Estrogen related receptor models: Investigation of selective agonist activity and transcriptional responses in cultured cells.
Metabolic and energy regulation studies: Evaluation of effects on mitochondrial and metabolic pathway markers in experimental systems.
Nuclear receptor comparative research: Assessment of receptor selectivity relative to other ERR modulators in controlled laboratory settings.
Cellular stress and adaptation models: Use as a probe for ERR mediated responses under metabolic challenge conditions.
Analytical Validation, Formulation, and Storage
NextGenPeps supplies DY131 as a high purity research compound. Typical quality and handling features include:
Purity: ≥98% verified by HPLC.
Formulation: Solid material in sealed containers, intended for dissolution with appropriate research grade solvent for experimental use only. No dosing guidance is provided for any organism.
Storage: Keep material in a cool dark dry environment; recommended storage at or near 4 °C. Handle reconstituted solutions according to laboratory defined stability windows.
NextGenPeps supplies DY131 as a high purity research compound intended strictly for controlled laboratory use in vitro or in established animal models, such as murine systems. This compound is not approved as a drug, diagnostic, or dietary ingredient, and is not manufactured, packaged, or marketed for human consumption, self experimentation, clinical application, or any use outside properly designed and ethically approved research protocols.
Compound information
- Molecular Formula
- C₁₈H₁₈N₂O₂
- Molecular Weight
- 294.35
- Monoisotopic Mass
- 294.1368
- Heavy Atom Count
- 22
Frequently asked questions
How is DY-131 shipped?
Orders are shipped within the United States via USPS. Transit times are typically 3–7 business days, depending on destination and carrier conditions. Tracking information is provided when available.
How should DY-131 be stored?
Storage requirements are product-specific. Keep DY-131 in its original labeled container and follow the product documentation or manufacturer instructions supplied with the order. Contact support if the applicable storage guidance is not available.
What is the refund policy for DY-131?
Due to the nature of research materials, NextGenPeps orders are final and are not eligible for refunds, returns, or exchanges. Review the shipping and reship policies before ordering.
Is DY-131 intended for human use?
No. NextGenPeps materials are supplied strictly for laboratory research and development use and are not intended for human or animal consumption, clinical use, diagnostic use, cosmetic use, or dietary use.
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Common research questions
What is DY131?
DY131 is a lab-made small molecule, not a peptide, used almost exclusively as a laboratory research tool. It's a potent and selective agonist for two nuclear receptors called ERRγ and ERRβ, while having no effect on a related receptor called ERRα, or on the estrogen receptors ERα and ERβ. Those receptors it targets, ERRβ and ERRγ, are sometimes called "orphan" receptors because they're constitutively active on their own, without needing estrogen to bind to them, despite being structurally related to the estrogen receptor family.
What does DY131 do?
DY131 works by switching on the two receptors it targets, essentially forcing them into a more active state. At low concentrations it activates ERRβ a few times over baseline, and it activates ERRγ even more strongly, reaching over six times normal activity at higher concentrations. So functionally, it's mainly a tool scientists use to study what these particular receptors do inside cells, especially in cancer research, rather than something with any broader therapeutic use on its own.
What is a similar compound to DY131?
GSK5182 is the closest match, since it targets the exact same receptor, ERRγ, but does the opposite job. GSK5182 is an inverse agonist, meaning it suppresses ERRγ activity rather than activating it, and works partly by preventing the receptor from being broken down inside the cell.
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