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Adipotide Research Peptide Overview
Adipotide (also known as FTPP or Fat-Targeted Proapoptotic Peptide) is a synthetic chimeric peptidomimetic designed to selectively target the vasculature of white adipose tissue and induce apoptosis in associated endothelial cells in preclinical models.
Molecular Composition and Mechanistic Profile
Peptide identity: Adipotide is a bifunctional synthetic peptide consisting of a homing domain and a proapoptotic domain linked by a glycine-glycine spacer.
Origin: Engineered sequence typically represented as CKGGRAKDC-GG-D(KLAKLAK)₂.
Mechanistically, Adipotide has been associated with:
Selective binding of the CKGGRAKDC motif to prohibitin and annexin A2 receptor complexes expressed on the surface of endothelial cells supplying white adipose tissue.
Internalization of the proapoptotic (KLAKLAK)₂ domain, which disrupts mitochondrial membrane integrity and triggers programmed cell death in the targeted vasculature.
Subsequent reduction of blood supply to white adipose depots, leading to tissue remodeling observed in experimental systems.
These properties position Adipotide as a tool for studying targeted vascular apoptosis and adipose tissue dynamics.
Integrated Research Applications
Adipose tissue vascular models: Investigation of selective endothelial targeting and apoptosis in white fat vasculature using cultured cells and animal tissue preparations.
Metabolic tissue remodeling studies: Evaluation of changes in adipose mass, vascular density, and related metabolic markers in obese rodent and non-human primate models.
Prohibitin receptor research: Use as a ligand-directed probe to explore the distribution and function of prohibitin-annexin A2 complexes in endothelial cells.
Comparative proapoptotic peptide studies: Assessment of homing specificity and apoptotic efficiency relative to non-targeted control sequences in controlled laboratory settings.
Overall, Adipotide serves as a research tool for exploring ligand-directed vascular disruption and its downstream effects on adipose tissue in experimental systems.
Analytical Validation, Formulation, and Storage
NextGenPeps supplies Adipotide as a high-purity research peptide. Typical quality and handling features include:
Purity: ≥99% verified by HPLC.
Formulation: White lyophilized powder in sealed glass vials, intended for reconstitution with appropriate research-grade solvent for experimental use only. No dosing guidance is provided for any organism.
Storage: Keep lyophilized material in a cool, dark, dry environment; long-term storage at or below −20 °C. Store reconstituted solutions refrigerated, minimize freeze-thaw cycles, and use within laboratory-defined stability windows.
NextGenPeps supplies Adipotide as a high-purity research peptide intended strictly for controlled laboratory use in vitro or in established animal models, such as murine systems. This compound is not approved as a drug, diagnostic, or dietary ingredient, and is not manufactured, packaged, or marketed for human consumption, self-experimentation, clinical application, or any use outside properly designed and ethically approved research protocols.
