5-Amino-1MQ is a synthetic small molecule that acts as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). It is used in research focused on fat metabolism, energy balance, and cellular health.
What makes 5-Amino-1MQ interesting is its ability to block NNMT, an enzyme that rises in obesity and aging. This helps maintain higher NAD+ levels, supporting better mitochondrial function and shifting metabolism toward fat burning instead of storage.
Its main effects center on adipose tissue and cellular energy:
It inhibits NNMT, which raises NAD+ availability and improves mitochondrial performance.
It reduces new fat formation in fat cells and promotes breakdown of stored fat, resulting in smaller adipocytes.
In animal studies it has lowered white adipose tissue mass and body weight while improving metabolic markers, typically without major changes in food intake.
Emerging work looks at its potential in muscle biology, where NNMT inhibition may support muscle stem cell function and regeneration.
Integrated Research Applications
5-Amino-1MQ is primarily studied for metabolic and obesity-related questions but also shows promise in muscle and cellular energy research:
Most studies examine its role in fat loss and body composition. In obese rodent models it has reduced fat mass and adipocyte size while helping preserve lean tissue.
It is used to explore improvements in insulin sensitivity and glucose handling in metabolic research.
Some work investigates muscle regeneration, where NNMT inhibition appears to enhance stem cell activity and myoblast differentiation in aged models.
Researchers also use it to study NAD+-related pathways, sirtuin activation, and age-related metabolic changes.
Analytical Validation, Formulation, and Storage
Research grade 5-Amino-1MQ is supplied as a high purity solid, often as a powder, in glass vials with purity typically verified by HPLC and a batch-specific certificate of analysis.
Formulation: Solid material for reconstitution with an appropriate aqueous solvent. No dosing instructions are provided.
Storage follows standard peptide and small molecule handling:
Keep the solid form at or below -20°C in a cool, dark, dry place.
After reconstitution, store at 2-8°C, avoid repeated freeze-thaw cycles, and use within standard laboratory timeframes.
NextGenPeps supplies 5-Amino-1MQ as a high purity research compound intended strictly for controlled laboratory use in vitro or in established animal models. This compound is not approved as a drug, diagnostic, or dietary ingredient, and is not manufactured, packaged, or marketed for consumption, self-experimentation, clinical application, or any use outside properly designed and ethically approved research protocols.