How is IGF-1 LR3 packaged?
IGF-1 LR3 is supplied in the product format and quantity shown for the selected variant. Please inspect the sealed package when it arrives and contact support promptly if the package or labeling appears damaged.
IGF-1 LR3 Peptide
Out of stock
IGF-1 LR3 1mg vials, the 83-amino-acid Long R3 analog of insulin-like growth factor 1. Tested for purity, content and endotoxins, COA published.
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Product details
GF DES is a truncated analog of insulin like growth factor 1 investigated for its enhanced interactions with the IGF 1 receptor and reduced binding to IGF binding proteins in preclinical models.
Molecular Composition and Mechanistic Profile
Peptide identity: IGF DES is a sixty seven amino acid peptide corresponding to IGF 1 lacking the first three N terminal residues Gly Pro Glu.
Origin: Truncated form of native IGF 1, occurring naturally in some tissues and produced synthetically for research.
Mechanistically, IGF DES has been associated with:
Higher potency at the IGF 1 receptor due to substantially reduced affinity for IGF binding proteins in experimental systems.
Activation of downstream growth and metabolic signaling pathways in cellular preparations.
Localized and potent receptor engagement observed in laboratory models of IGF 1 activity.
Integrated Research Applications
IGF DES is examined in systems focused on insulin like growth factor biology. Representative domains include:
IGF 1 receptor models: Investigation of receptor activation and downstream signaling in cultured cells.
Cell proliferation and hypertrophy studies: Evaluation of growth related responses in experimental tissue systems.
Binding protein interaction research: Assessment of reduced IGFBP affinity relative to native IGF 1 in controlled laboratory settings.
Comparative IGF analog research: Use as a truncated probe for exploring potency and localization differences among IGF variants.
Overall, IGF DES serves as a research tool for exploring truncated IGF 1 modulation of receptor mediated growth and metabolic networks.
Analytical Validation, Formulation, and Storage
NextGenPeps supplies IGF DES as a high purity research peptide. Typical quality and handling features include:
Purity: ≥99% verified by HPLC.
Formulation: White lyophilized powder in sealed glass vials, intended for reconstitution with appropriate research grade solvent for experimental use only. No dosing guidance is provided for any organism.
Storage: Keep lyophilized material in a cool dark dry environment; long term storage at or below −20 °C. Store reconstituted solutions refrigerated, minimize freeze thaw cycles, and use within laboratory defined stability windows.
These conditions support structural integrity and reproducible experimental outcomes.
NextGenPeps supplies IGF DES as a high purity research peptide intended strictly for controlled laboratory use in vitro or in established animal models, such as murine systems. This compound is not approved as a drug, diagnostic, or dietary ingredient, and is not manufactured, packaged, or marketed for human consumption, self experimentation, clinical application, or any use outside properly designed and ethically approved research protocols.
Compound information
- Molecular Formula
- C₄₀₀H₆₂₄N₁₀₈O₁₁₅S₉
- Molecular Weight
- 9111–9117
- Monoisotopic Mass
- 9105
- Heavy Atom Count
- 640
Frequently asked questions
How is IGF-1 LR3 shipped?
Orders are shipped within the United States via USPS. Transit times are typically 3–7 business days, depending on destination and carrier conditions. Tracking information is provided when available.
How should IGF-1 LR3 be stored?
Storage requirements are product-specific. Keep IGF-1 LR3 in its original labeled container and follow the product documentation or manufacturer instructions supplied with the order. Contact support if the applicable storage guidance is not available.
What is the refund policy for IGF-1 LR3?
Due to the nature of research materials, NextGenPeps orders are final and are not eligible for refunds, returns, or exchanges. Review the shipping and reship policies before ordering.
Is IGF-1 LR3 intended for human use?
No. NextGenPeps materials are supplied strictly for laboratory research and development use and are not intended for human or animal consumption, clinical use, diagnostic use, cosmetic use, or dietary use.
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Common research questions
What is IGF-1 LR3?
IGF-1 LR3 is a lab-modified version of a hormone the body already makes naturally, called IGF-1 (Insulin-like Growth Factor 1). Compared to natural IGF-1, which is 70 amino acids long, IGF-1 LR3 has 83 amino acids, with two key changes: one amino acid swapped near the start of the chain, and an extra 13-amino-acid stretch added to the front. They dramatically reduce how strongly the peptide binds to certain proteins in the blood that normally trap and limit natural IGF-1, which is what gives the modified version its main advantage.
What does IGF-1 LR3 do?
The biggest practical difference between IGF-1 LR3 and natural IGF-1 comes down to how long it lasts in the body. Natural IGF-1 only stays active for a few minutes, while IGF-1 LR3 can remain active for roughly 20 to 30 hours, giving it a much longer window to act. It works by attaching to a specific receptor found on muscle cells and several other tissue types. Binding to this receptor triggers two major internal signaling pathways, one that supports protein production and cell survival, and another that drives cell growth and division. In muscle specifically, that translates into a few different effects. It's thought to support muscle growth in two ways, by helping create new muscle cells and by helping existing muscle fibers develop further, which is why it's a peptide of interest for both muscle building and recovery after injury.
What is the closest peptide to IGF-1 LR3?
The closest comparison is IGF-1 DES, another modified version of IGF-1 that also resists binding to those same blood proteins, though it does so through a different structural change, and it tends to act faster but for a shorter window than LR3. PEG-MGF is another frequently compared peptide, since MGF is a naturally occurring, locally acting relative of IGF-1 that gets produced quickly in muscle right after damage or exercise, whereas IGF-1 LR3 acts more broadly throughout the body over a longer period of time.
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