AlphaKlothoLR is a modified recombinant form of the α-Klotho protein engineered with an albumin binding construct for extended activity, investigated in preclinical models of aging related signaling, mineral metabolism, and cellular stress responses.
Molecular Composition and Mechanistic Profile
Compound identity: AlphaKlothoLR is a long-release recombinant α-Klotho construct incorporating a proprietary albumin-binding peptide sequence linked via glycine-serine spacers.
Origin: Derived from the full length or domain-focused α-Klotho protein and modified to prolong circulatory half-life and sustained receptor interaction in experimental systems.
Mechanistically, AlphaKlothoLR has been associated with:
Function as a co-receptor with FGF receptors (primarily FGFR1c, FGFR3c, FGFR4) to facilitate FGF23 signaling involved in phosphate and vitamin D homeostasis.
Modulation of Wnt, TGF-β, and related pathways that influence tissue remodeling, oxidative stress, and inflammatory signaling in laboratory models.
Extended presence due to albumin binding, supporting prolonged engagement with target pathways compared to unmodified soluble α-Klotho.
These properties make AlphaKlothoLR a tool for studying sustained α-Klotho-related signaling in controlled research environments.
Integrated Research Applications
AlphaKlothoLR is examined across systems linked to α-Klotho biology. Representative domains include:
Mineral metabolism and renal models: Investigation of FGF23 co-receptor activity, phosphate handling, and related homeostatic pathways in cell and animal preparations.
Aging and stress-response models: Evaluation of effects on oxidative stress markers, inflammatory cascades, and tissue resilience pathways in experimental systems.
Fibrosis and tissue remodeling studies: Assessment of Wnt and TGF-β modulation in organ-specific injury or fibrotic models.
Comparative longevity factor research: Use as a prolonged activity probe relative to native or short-acting α-Klotho forms in laboratory settings.
Overall, AlphaKlothoLR serves as a research tool for exploring extended α-Klotho signaling and its intersections with metabolic and stress-adaptation networks.
Analytical Validation, Formulation, and Storage
NextGenPeps supplies AlphaKlothoLR as a high-purity research compound. Typical quality and handling features include:
Purity: ≥99% verified by HPLC.
Formulation: Lyophilized powder in sealed glass vials, intended for reconstitution with appropriate research-grade solvent for experimental use only. No dosing guidance is provided for any organism.
Storage: Keep lyophilized material in a cool, dark, dry environment; long-term storage at or below −20 °C. Store reconstituted solutions refrigerated, minimize freeze-thaw cycles, and use within laboratory-defined stability windows.
These conditions support structural integrity and reproducible experimental outcomes.
NextGenPeps supplies AlphaKlothoLR as a high-purity research compound intended strictly for controlled laboratory use in vitro or in established animal models, such as murine systems. This compound is not approved as a drug, diagnostic, or dietary ingredient, and is not manufactured, packaged, or marketed for human consumption, self-experimentation, clinical application, or any use outside properly designed and ethically approved research protocols.
