Alpha Klotho LR

AlphaKlothoLR is a modified recombinant form of the α-Klotho protein engineered with an albumin binding construct for extended activity, investigated in preclinical models of aging related signaling, mineral metabolism, and cellular stress responses.

Molecular Composition and Mechanistic Profile

• Compound identity: AlphaKlothoLR is a long-release recombinant α-Klotho construct incorporating a proprietary albumin-binding peptide sequence linked via glycine-serine spacers.

• Origin: Derived from the full length or domain-focused α-Klotho protein and modified to prolong circulatory half-life and sustained receptor interaction in experimental systems.

• Mechanistically, AlphaKlothoLR has been associated with:

  • Function as a co-receptor with FGF receptors (primarily FGFR1c, FGFR3c, FGFR4) to facilitate FGF23 signaling involved in phosphate and vitamin D homeostasis.

  • Modulation of Wnt, TGF-β, and related pathways that influence tissue remodeling, oxidative stress, and inflammatory signaling in laboratory models.

  • Extended presence due to albumin binding, supporting prolonged engagement with target pathways compared to unmodified soluble α-Klotho.

These properties make AlphaKlothoLR a tool for studying sustained α-Klotho-related signaling in controlled research environments.

Integrated Research Applications

AlphaKlothoLR is examined across systems linked to α-Klotho biology. Representative domains include:

• Mineral metabolism and renal models: Investigation of FGF23 co-receptor activity, phosphate handling, and related homeostatic pathways in cell and animal preparations.

• Aging and stress-response models: Evaluation of effects on oxidative stress markers, inflammatory cascades, and tissue resilience pathways in experimental systems.

• Fibrosis and tissue remodeling studies: Assessment of Wnt and TGF-β modulation in organ-specific injury or fibrotic models.

• Comparative longevity factor research: Use as a prolonged activity probe relative to native or short-acting α-Klotho forms in laboratory settings.

Overall, AlphaKlothoLR serves as a research tool for exploring extended α-Klotho signaling and its intersections with metabolic and stress-adaptation networks.

Analytical Validation, Formulation, and Storage

NextGenPeps supplies AlphaKlothoLR as a high-purity research compound. Typical quality and handling features include:

• Purity: ≥99% verified by HPLC.

• Formulation: Lyophilized powder in sealed glass vials, intended for reconstitution with appropriate research-grade solvent for experimental use only. No dosing guidance is provided for any organism.

• Storage: Keep lyophilized material in a cool, dark, dry environment; long-term storage at or below −20 °C. Store reconstituted solutions refrigerated, minimize freeze-thaw cycles, and use within laboratory-defined stability windows.

These conditions support structural integrity and reproducible experimental outcomes.

NextGenPeps supplies AlphaKlothoLR as a high-purity research compound intended strictly for controlled laboratory use in vitro or in established animal models, such as murine systems. This compound is not approved as a drug, diagnostic, or dietary ingredient, and is not manufactured, packaged, or marketed for human consumption, self-experimentation, clinical application, or any use outside properly designed and ethically approved research protocols.