How is Pinealon packaged?
Pinealon is supplied in the product format and quantity shown for the selected variant. Please inspect the sealed package when it arrives and contact support promptly if the package or labeling appears damaged.
Pinealon Peptide
5.0· 3 reviewsout of 5In stock
Pinealon research vials, a short synthetic tripeptide supplied for laboratory use. Tested for purity and peptide content, and screened for endotoxins.
Product details
Pinealon Neuroregulatory Tripeptide Research Overview
Pinealon is a high-purity, research-grade synthetic tripeptide bioregulator composed of L‐glutamic acid, L‐aspartic acid, and L‐arginine (Glu‐Asp‐Arg, “EDR”). It is investigated for neuroprotective, nootropic, and circadian-modulating effects, with particular focus on central nervous system aging, oxidative stress resistance, and gene‐level regulation in neural tissues.
Molecular Composition and Mechanistic Profile
Mechanistic features reported in preclinical and technical literature include:
Direct interaction with DNA and chromatin, classifying Pinealon as a peptide bioregulator capable of modulating gene expression patterns related to neuronal metabolism, stress resistance, and brain plasticity.
Neuroprotective activity via reduction of reactive oxygen species (ROS) accumulation, modulation of MAPK/ERK signaling, and anti‐apoptotic effects through caspase‐3 pathway regulation.
Potential to influence serotonin synthesis and other neurotransmitter pathways, with reports of ~1.9‐fold increases in serotonin production in younger neural cell cultures.
These properties support its use as a tool for exploring epigenetic regulation, oxidative stress defense, and neuronal survival.
Integrated Research Applications
Pinealon is used across CNS‐focused and longevity research domains. Representative applications include:
Neuroprotection and ischemia/hypoxia models: Assessment of neuronal survival, ROS levels, mitochondrial function, and apoptosis under hypoxic or oxidative challenge.
Cognitive and behavioral research: Studies of learning, memory retention, attention, and age‐related cognitive decline, often in rodent models.
Circadian rhythm and sleep: Investigation of Pinealon’s influence on pineal‐gland signaling, circadian regulation, and sleep–wake patterns, especially in aging CNS contexts.
Longevity and anti‐aging research: Evaluation of how Pinealon mitigates age‐associated changes in the brain, including structural, oxidative, and behavioral endpoints.
Because of its very short sequence and small size, Pinealon is also studied for membrane and nuclear penetration properties distinct from larger peptides.
Analytical Validation, Formulation, and Storage
Pinealon research products from these vendors are typically supplied as lyophilized powder (e.g., 10 mg or 20 mg per vial).
Form: White to off‐white lyophilized powder intended for reconstitution with
appropriate sterile diluent for in vitro or in vivo research. Storage and care (aligned with your standard wording):
Store vials in a cool, dry place away from light while lyophilized.
After constitution, refrigerate the solution; for longer‐term storage, freezing atapproximately −20 °C is recommended to maintain integrity.
NextGenPeps provides Pinealon strictly for laboratory research purposes. It is not approved for human use and is not intended for consumption, diagnosis, or treatment outside controlled and ethically reviewed experimental settings.
Compound information
- Molecular Formula
- C₁₅H₂₆N₆O₈
- Molecular Weight
- 418.4–432.43 g/mol
- Sequence Length
- 3 amino acids
Test results · this lot
99.54%
HPLC purity · Tested by Bioviridian
- Tested
- Sep 25, 2026
- Labeled
- 10mg / Vial
- Lab
- Bioviridian
- PurityHPLC99.54%Tested
- EndotoxinPer vial<0.05 EU/mlTested
- All certificatesCOA libraryBrowseLibrary
Frequently asked questions
How is Pinealon shipped?
Orders are shipped within the United States via USPS. Transit times are typically 3–7 business days, depending on destination and carrier conditions. Tracking information is provided when available.
How should Pinealon be stored?
Storage requirements are product-specific. Keep Pinealon in its original labeled container and follow the product documentation or manufacturer instructions supplied with the order. Contact support if the applicable storage guidance is not available.
What is the refund policy for Pinealon?
Due to the nature of research materials, NextGenPeps orders are final and are not eligible for refunds, returns, or exchanges. Review the shipping and reship policies before ordering.
Is Pinealon intended for human use?
No. NextGenPeps materials are supplied strictly for laboratory research and development use and are not intended for human or animal consumption, clinical use, diagnostic use, cosmetic use, or dietary use.
Customer reviews
Common research questions
What is Pinealon?
Pinealon is a synthetic tripeptide composed of the amino acids glutamic acid, asparagine, and arginine. It belongs to a class of short peptide bioregulators developed by Russian researchers, similar in origin to Epithalon. Pinealon is designed to mimic peptides naturally produced by the pineal gland. It is studied for its small size, which allows it to cross the blood-brain barrier easily. Researchers primarily investigate Pinealon in the context of neuroprotection and brain cell function.
What does Pinealon do?
Pinealon is studied for its ability to regulate gene expression involved in neuron protection and repair. It supports research into antioxidant activity, helping reduce oxidative stress in brain tissue. Research shows Pinealon may influence the survival of neurons under conditions of stress or aging. It is examined for its role in supporting cognitive function, including memory and learning processes in experimental models. Pinealon also shows potential in studies related to central nervous system recovery following injury.
How does Pinealon differ from larger neuropeptides?
As a short tripeptide (Glu‐Asp‐Arg), Pinealon appears able to cross cellular and possibly nuclear membranes more readily than larger peptides, enabling direct DNA/chromatin interactions rather than acting solely through surface receptors.
Pinealon compared to Selank
Pinealon is a tripeptide bioregulator studied for gene regulation, neuroprotection, and antioxidant activity within brain cells. Selank is a synthetic peptide derived from the immune modulator tuftsin, studied for anxiolytic effects and immune-nervous system interaction. Pinealon excels in research on cellular-level brain aging and neuronal repair, while Selank emphasizes emotional regulation and stress response pathways. Both peptides are studied for cognitive support, but through different mechanisms, one centered on gene expression and the other on neuropeptide and immune signaling.
Pinealon compared to Semax
Pinealon is a short tripeptide bioregulator studied for its role in gene expression, neuroprotection, and reducing oxidative stress in brain cells. Semax is a synthetic peptide derived from ACTH, studied for its effects on BDNF production and cognitive enhancement. Pinealon excels in research on cellular aging and long-term neuronal support, while Semax emphasizes acute cognitive performance and neurotrophic factor stimulation. Both peptides are studied for brain health, but Pinealon works at the genomic level while Semax acts more directly on neurotransmitter and growth factor systems.
