How is Cagrilintide packaged?
Cagrilintide is supplied in the product format and quantity shown for the selected variant. Please inspect the sealed package when it arrives and contact support promptly if the package or labeling appears damaged.
Cagrilintide Peptide
4.8· 4 reviewsout of 5In stock
Cagrilintide research vials, a long-acting amylin analog supplied for laboratory use. Tested for purity, peptide content and endotoxins, COA published.
Product details
Cagrilintide (CAG) Amylin-Pathway Research Overview
Cagrilintide is a long-acting, research-grade analog of human amylin, engineered to activate amylin and calcitonin-family receptors while resisting aggregation and enzymatic breakdown. It is used to model appetite control, gastric emptying, and glucose regulation in metabolic research.
Molecular Composition and Mechanistic Profile
Mechanistically, Cagrilintide:
Acts as a non‐selective agonist at amylin receptors (AMY1R, AMY2R, AMY3R) and the calcitonin receptor (CTR), all of which are CTR/RAMP heterodimers in the calcitonin receptor family.
Engages brainstem and hypothalamic circuits (notably in the area postrema and related nuclei) to decrease food intake, increase satiety, slow gastric emptying, and ultimately lower body weight in animal studies.
Shows distinct binding dynamics versus native amylin and salmon calcitonin, with cryo‐EM data indicating unique conformational effects on CTR/RAMP complexes that may underlie its robust and durable anorectic activity.
These features make Cagrilintide a key tool for dissecting long‐acting amylin‐pathway pharmacology in obesity and diabetes research.
Integrated Research Applications
Cagrilintide is investigated across several metabolic and endocrine research areas:
Combination incretin–amylin strategies: Trials combining Cagrilintide with GLP‐1 analogues (e.g., semaglutide, in “CagriSema” constructs) demonstrate improved glycemic control compared to either agent alone.
Type 2 diabetes and glycemic control: Research explores its effects on fasting glucose, HbA1c, and post‐prandial glycemia via slowed gastric emptying, reduced food intake, and possible direct pancreatic/islet effects.
Liver and cardiovascular markers: Cagrilintide is also studied for impacts on liver fat, cardiovascular risk markers, and systemic metabolic signaling, including lipid profiles.
Because it is long‐acting and aggregation‐resistant, Cagrilintide enables chronic dosing protocols that more closely mimic prospective therapeutic scenarios.
Analytical Validation, Formulation, and Storage
Research suppliers provide Cagrilintide as a lyophilized, white to off‐white powder (typically 10 mg per vial) intended for reconstitution prior to experimental use. Key quality and handling characteristics include:
Purity: High (often ≥98–99%) verified by HPLC and complementary analytical methods.
Identity: Confirmed by mass spectrometry and peptide mapping consistent with the C194H312N54O59S2 composition and amylin‐analogue sequence.
Solubility: Slightly soluble in DMSO (≈0.1–1 mg/mL) and sparingly soluble in aqueous buffers such as PBS; formulation often requires careful pH and solvent selection.
Product care, matching your house style:
Store vials in a cool, dry place away from light while lyophilized.
After constitution with appropriate lab‐grade diluent, refrigerate the solution; for longer‐term storage, freezing at approximately −20 °C is recommended to preserve peptide integrity.
NextGenPeps supplies cagrilintide as a high-purity research compound intended exclusively for laboratory use. It is not approved for therapeutic, diagnostic, or dietary purposes and is not intended for human administration or self-experimentation.
Compound information
- Molecular Formula
- C₁₉₄H₃₁₂N₅₄O₅₉S₂
- Molecular Weight
- 4409.0–4409.01
- XLogP3
- −12.5 (highly hydrophilic peptide)
- Topological Polar Surface Area
- ~1880 Å2
- Heavy Atom Count
- 309
- Complexity
- 10,800
Test results · this lot
99.74%
HPLC purity · Tested by Bioviridian
- Tested
- Sep 25, 2026
- Labeled
- 10mg / Vial
- Lab
- Bioviridian
- PurityHPLC99.74%Tested
- EndotoxinPer vial<0.05 EU/mlTested
- All certificatesCOA libraryBrowseLibrary
Frequently asked questions
How is Cagrilintide shipped?
Orders are shipped within the United States via USPS. Transit times are typically 3–7 business days, depending on destination and carrier conditions. Tracking information is provided when available.
How should Cagrilintide be stored?
Storage requirements are product-specific. Keep Cagrilintide in its original labeled container and follow the product documentation or manufacturer instructions supplied with the order. Contact support if the applicable storage guidance is not available.
What is the refund policy for Cagrilintide?
Due to the nature of research materials, NextGenPeps orders are final and are not eligible for refunds, returns, or exchanges. Review the shipping and reship policies before ordering.
Is Cagrilintide intended for human use?
No. NextGenPeps materials are supplied strictly for laboratory research and development use and are not intended for human or animal consumption, clinical use, diagnostic use, cosmetic use, or dietary use.
Customer reviews
Common research questions
What is Cagrilintide?
Cagrilintide is a long acting synthetic peptide analog of amylin, a hormone naturally secreted with insulin from pancreatic beta cells, developed primarily for metabolic research. Cagrilintide is engineered with acylation to improve stability and extend its half-life, it functions as a "dual amylin and calcitonin receptor agonist" (DACRA). This modification allows cagrilintide to resist rapid enzymatic degradation compared to native amylin, making it suitable for long form studies in research models. Researchers investigate cagrilintide in obesity and diabetes models due to its effects on appetite regulation and gastric emptying.
What is Cagrilintide peptide used for?
In research, cagrilintide is studied for its ability to activate amylin receptors in the brain, promoting satiety signals, slowing gastric emptying, and reducing food intake in animal and in vitro models. It is frequently examined in combination therapies with GLP-1 receptor agonists to explore synergistic effects on metabolic parameters. Preclinical studies highlight its potential in modulating glucagon secretion and improving glucose control through calcitonin receptor pathways. Researchers mainly use cagrilintide to investigate long term appetite suppression mechanisms and energy balance in metabolic disorder models.
What is Cagrilintide versus GLP-TZ?
Cagrilintide targets amylin and calcitonin receptors to enhance satiety and slow gastric emptying, while GLP-TZ acts as both a GLP-1 and GIP receptor agonist that primarily boosts insulin secretion and suppresses glucagon. In comparative preclinical research, cagrilintide shows strong effects on appetite control, whereas GLP-TZ often demonstrates broader impacts on glycemic control and energy expenditure.
How do you Store Cagrilintide?
Cagrilintide research peptide is supplied as lyophilized powder and should be stored at around -20°C for long term stability, protecting it from moisture and light in sealed vials. Short term refrigeration at 2-8°C is suitable for several weeks prior to reconstitution. After reconstitution with bacteriostatic water, the solution is stored in a refrigerator esc environment at 2-8°C. Avoid repeated freeze thaw cycles and keep vials away from direct light. Proper aliquoting into smaller volumes helps minimize contamination risks during laboratory handling.
